{"id":10940,"date":"2021-09-28T21:48:36","date_gmt":"2021-09-28T18:48:36","guid":{"rendered":"http:\/\/kaplanlab.com\/?p=10940"},"modified":"2021-10-20T00:24:09","modified_gmt":"2021-10-19T21:24:09","slug":"ciliary-genes","status":"publish","type":"post","link":"http:\/\/kaplanlab.com\/ciliary-genes\/","title":{"rendered":"Ciliary Genes"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\"  style='background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1 fusion-builder-column-1 fusion-one-full fusion-column-first fusion-column-last 1_1\"  style='margin-top:0px;margin-bottom:20px;'>\n\t\t\t\t\t<div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"   data-bg-url=\"\">\n\t\t\t\t\t\t<div class=\"fusion-text\"><h2 style=\"text-align: center;\">Systems Medicine for Ciliary Genes<\/h2>\n<\/div><div class=\"fusion-text\"><p style=\"text-align: justify;\">Cilia are an antenna like organelle whose inner basic structure consists of a microtubule-based cytoskeleton namely the ciliary axoneme. Cilia extend from most of cell surfaces, where they act as sensor, perform motility function and regulate embryo development.We employ bioinformatic approaches to identify the unknown ciliary genes that build cilia and transition zone. We use\u00a0C. elegans.\u00a0as the primary model organism to confirm the expression and localization of candidate ciliary genes in the ciliated sensory neurons (Figure 1, localization of one candidate gene is shown).<\/p>\n<\/div><span class=\"fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img loading=\"lazy\" src=\"http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene.png\" width=\"1143\" height=\"401\" alt=\"\" title=\"CandidateGene\" class=\"img-responsive wp-image-10941\" srcset=\"http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene-200x70.png 200w, http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene-400x140.png 400w, http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene-600x210.png 600w, http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene-800x281.png 800w, http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene.png 1143w\" sizes=\"(max-width: 800px) 100vw, 1143px\" \/><\/span><div class=\"fusion-text\"><p style=\"text-align: justify;\">Figure 1: Shown are fluorescence images for transgenic worms expressing GFP labelled ciliary candidate gene . GFP tagged ciliary candidate gene is exclusively expressed in the ciliated sensory neurons , where it was found to localize to the cilium.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":10941,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ciliary Genes - Kaplan Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/kaplanlab.com\/ciliary-genes\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ciliary Genes - Kaplan Lab\" \/>\n<meta property=\"og:url\" content=\"http:\/\/kaplanlab.com\/ciliary-genes\/\" \/>\n<meta property=\"og:site_name\" content=\"Kaplan Lab\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-28T18:48:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-10-19T21:24:09+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/kaplanlab.com\/wp-content\/uploads\/2021\/09\/CandidateGene.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1143\" \/>\n\t<meta property=\"og:image:height\" content=\"401\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"kaplanadmin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"kaplanadmin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/kaplanlab.com\/ciliary-genes\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/kaplanlab.com\/ciliary-genes\/\"},\"author\":{\"name\":\"kaplanadmin\",\"@id\":\"http:\/\/kaplanlab.com\/#\/schema\/person\/5408d819af49ce3a60760c834e69f6c5\"},\"headline\":\"Ciliary Genes\",\"datePublished\":\"2021-09-28T18:48:36+00:00\",\"dateModified\":\"2021-10-19T21:24:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/kaplanlab.com\/ciliary-genes\/\"},\"wordCount\":650,\"commentCount\":0,\"publisher\":{\"@id\":\"http:\/\/kaplanlab.com\/#organization\"},\"articleSection\":[\"General\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"http:\/\/kaplanlab.com\/ciliary-genes\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/kaplanlab.com\/ciliary-genes\/\",\"url\":\"http:\/\/kaplanlab.com\/ciliary-genes\/\",\"name\":\"Ciliary Genes - 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